IL10 gene polymorphism is associated with preschool atopy and early-life asthma after bronchiolitis in infancy

Korppi (MK), Nuolivirta (KN), Lauhkonen (EL), Holster (AH), Teräsjärvi (JT), Vuononvirta (JV), Helminen (MH), He (QH), Koponen (PK) IL10 gene polymorphism is associated with preschool atopy and early-life asthma after bronchiolitis in infancy background: Variations in genes regulating innate immunity responses may be associated with susceptibility to asthma or atopy after early-life bronchiolitis. The aim of the study was to evaluate the association between 4 different polymorphisms of the IL-10 gene at rs1800871, rs1800872, rs1800890 and rs1800896 either alone or in combinations, and post-bronchiolitis asthma or allergy at 5-to 7-years of age. methods: Data on single nucleotide polymorphisms (SNP) of IL10 rs1800896 (-1082G/A), rs1800871 (-819C/T), rs1800872 (-592C/A) and IL10 rs1800890 (-3575T/A) were available for 135 children. Polymorphisms and their associations with asthma and allergy were studied in 135 preschool-aged children hospitalized for bronchiolitis at age 0-6 months. Parents were interviewed to record asthma and allergy from infancy to present. results: At 6.4 years (mean) asthma was present in 17 (12.6%), and doctor-diagnosed asthma during the first seven years of life was present in 39 (28.9%) children. 53 (39.3%) study participants had current atopy (atopic eczema or allergic rhinitis). Eight (72%) of 11 children with the IL10 rs1800896, IL10 rs1800871 and IL10 rs1800872 combination AA + CT + CA had current atopy (p=0.02 vs. 38% in other genotype combinations). 23 (56%) children with the IL10 rs1800871 C/T or IL10 rs1800872 C/A genotype had present atopy versus 34 (38%) with other IL10 genotypes (p=0.03). Between 2 and 3 years of age, 27% of ATA haplotype carriers had asthma vs. 13.7% of other haplotype carriers (p=0.02). conclusions: IL10 polymorphisms at rs1800871, rs1800872, rs1800890 and rs1800896 seem to associate with elevated allergy and/or asthma risk in later childhood after early-life bronchiolitis